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But the most important consideration here that we should underline is that the relative “liver toxicity” of anabolic steroids that are injectable and oil-based is generally not a major consideration, because these compounds are basically metabolized the same as the natural testosterone that is already in the body. However, we may see liver enzyme increases just because the liver is working to remove these steroids, the same as it does any other foreign chemical. Commonly, studies that focus on steroid toxicity often use absurd doses, or incorrectly focus on liver activity instead of damage, nandrophenyl 100 mg. The liver functions as the filter for the human body. It?s going to be activated whenever something (not just a steroid) passes through it. Does that show that steroids damage the liver? Alternative routes like IM or sub-Q injection avoid the first-pass effect because they allow drugs to be absorbed directly into the systemic circulation. Thus, they are much less harmful. However, some 17 alpha-alkylated steroids can be injected IM (stanozolol, methandrostenolone) and may cause problems at high doses or for prolonged periods. A computer search of the medical literature looking for steroid-associated liver tumors could find only three in athletes (Friedl, 1990). Of the three athletes, one was using 700 mg of oxymetholone a week for five straight years, and one had a tumor more indicative of classic liver cancer than of steroid-associated tumors. Virtually all of the reported liver problems seemed to occur with the 17 alpha-alkylated oral steroids. There have been no cysts or liver tumors reported in athletes using the 17 beta-esterified injectable steroids (Wright & Cowart, ). It has been noted that injectable steroids generally appear to have little effect on the liver at all (Haupt, 1993,). Recent studies continue to suggest that reports of serious adverse effects of anabolic steroids upon the liver in healthy athletes may be highly overstated. In a study of athletes, of the 53 current or past steroid users who underwent laboratory testing, only one subject displayed an abnormal liver test (Pope & Katz, 1994, p. Oxymetholone, formerly known as Anadrol in the U. The results were significant gains in lean muscle mass — even without any weightlifting. Even more importantly – and surprisingly — there were no significant problems with liver function, water retention, or virilization side effects (it will be interesting to see whether further studies yield consistent findings at such high dosages). There was an eight-week study (Molano F, 1999), which looked at the effects of an 8-week cycle of Oral steroids. 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